
Professor Simon MacKay
Strathclyde Institute of Pharmacy and Biomedical Sciences
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Prize And Awards
- Fellow of the Royal Pharmaceutical Society (FRPS)
- Recipient
- 2024
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Publications
- IL-1β stimulates a novel axis within the NFκB pathway in endothelial cells regulated by IKKα and TAK-1
- Craig Rachel, McIntosh Kathryn, Ho Ka Ho, McCulloch Ashley, Riley Christopher, Lawson Christopher, MacKay Simon P, Paul Andrew, Coats Paul, Plevin Robin
- Biochemical Pharmacology Vol 232 (2025)
- https://doi.org/10.1016/j.bcp.2024.116736
- 233 Targeting non-canonical NF-κB signalling in CYLD cutaneous syndrome by selective inhibition of IκB kinase alpha
- Hodgson K, Inns J, Reynolds G, Stephenson E, Frey A, Trost M, Haniffa M, Mackay S, Perkins N, Rajan N
- Journal of Investigative Dermatology Vol 144, pp. S268 (2024)
- https://doi.org/10.1016/j.jid.2024.10.241
- Design and synthesis of novel aminoindazole-pyrrolo[2,3-b]pyridine inhibitors of IKKα that selectively perturb cellular non-canonical NF-κB signalling
- Riley Christopher, Ammar Usama, Alsfouk Aisha, Anthony Nahoum G, Baiget Jessica, Berretta Giacomo, Breen David, Huggan Judith, Lawson Christopher, McIntosh Kathryn, Plevin Robin, Suckling Colin J, Young Louise C, Paul Andrew, Mackay Simon P
- Molecules Vol 29 (2024)
- https://doi.org/10.3390/molecules29153515
- IL-1β stimulates a novel, IKKα -dependent, NIK -independent activation of non-canonical NFκB signalling
- McIntosh Kathryn, Khalaf Yousif H, Craig Rachel, West Christopher, McCulloch Ashley, Waghmare Ajay, Lawson Christopher, Chan Edmond YW, MacKay Simon, Paul Andrew, Plevin Robin
- Cellular Signalling Vol 107 (2023)
- https://doi.org/10.1016/j.cellsig.2023.110684
- JAK–STAT signalling shapes the NF‐κB response in CLL towards venetoclax sensitivity or resistance via Bcl‐XL
- Haselager Marco V, Thijssen Rachel, Bax Danique, Both Demi, De Boer Francien, Mackay Simon, Dubois Julie, Mellink Clemens, Kater Arnon P, Eldering Eric
- Molecular Oncology Vol 17, pp. 1112-1128 (2023)
- https://doi.org/10.1002/1878-0261.13364
- Interleukin-1b stimulates a novel early activation of non-canonical NF Kappa B signalling pathway linked to CXCL12 production.
- McIntosh Kathryn, Craig Rachel Georgina, McCulloch Ashley, MacKay Simon, Paul Andrew, Plevin Robin
- British Pharmacology annual conference (2022)
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Professional Activities
- Prostate Cancer UK (External organisation)
- Member
- 1/10/2015
- REF (External organisation)
- Member
- 1/1/2014
- Japanese Society for the Promotion of Science
- Invited speaker
- 6/9/2013
- Academy of Pharmaceutical Sciences
- Chair
- 3/9/2013
- Academy of Pharmaceutical Sciences
- Invited speaker
- 3/9/2013
- Finland Academy of Science (External organisation)
- Member
- 29/1/2013
Projects
- MRC-DPFS Full Application 2023 - Targeting Inhibitory kappa B kinase alpha (IKKalpha): a new treatment paradigm for inflammatory-driven cancers
- MacKay, Simon (Principal Investigator) Paul, Andrew (Co-investigator)
- 01-Jan-2024 - 31-Jan-2027
- TargoPep: a cell selective delivery platform for therapeutic payloads (Follow on Fund)
- Burley, Glenn (Principal Investigator) MacKay, Simon (Co-investigator) Perrie, Yvonne (Co-investigator) McWhinnie, Fergus (Research Co-investigator)
- 01-Jan-2023 - 30-Jan-2024
- Development of a first-in-class IKKalpha inhibitor for the treatment of castrate resistant p
- MacKay, Simon (Principal Investigator) Halbert, Gavin (Co-investigator) Paul, Andrew (Co-investigator) Suckling, Colin (Co-investigator) Watson, David (Co-investigator)
- 01-Jan-2020 - 31-Jan-2024
- CRUK evaluation of IKK inhibitors
- MacKay, Simon (Principal Investigator)
- 01-Jan-2018 - 31-Jan-2018
- David Begg / NSF Studentship | Webb, Cameron
- Perrie, Yvonne (Principal Investigator) MacKay, Simon (Co-investigator) Webb, Cameron (Research Co-investigator)
- 01-Jan-2018 - 16-Jan-2022
- Prevention of CXCL12 production in cells of the cardiovascular system by IKK alpha inhibition (BHF PhD Studentship)
- Plevin, Robin (Principal Investigator) Coats, Paul (Co-investigator) MacKay, Simon (Co-investigator) Paul, Andrew (Co-investigator)
- 01-Jan-2018 - 30-Jan-2022
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Contact
Professor
Simon
MacKay
Strathclyde Institute of Pharmacy and Biomedical Sciences
Email: simon.mackay@strath.ac.uk
Tel: 548 2866